Abiotic stresses such as salinity, ultraviolet radiation, and extreme temperatures accelerate the degradation of plant growth regulators (PGRs), limiting their efficacy in agriculture. Addressing these stressors requires not only agronomic innovation but also new molecular and materials approaches. Grounded in supramolecular chemistry and green synthetic principles, this dissertation focuses on the fabrication of metal-organic-based nanocarriers as platforms to stabilize labile bioactives and enable controlled release under environmental stressors. Three subclasses of metal–organic nanocarriers were designed and prepared through mild, green synthetic routes to encapsulate a specific PGR: (1) a zinc–imidazolate framework for a synthetic zaxinone mimic, (2) a lipid–phenolic core–shell system incorporating an iron–tannic acid network for indole-3-acetic acid, and (3) a zinc–caffeic acid metal–phenolic nanocarrier for N6-furfuryladenine (kinetin). 

Comprehensive physicochemical characterization, including spectroscopy, electron microscopy, X-ray diffraction, and release kinetics, revealed high encapsulation efficiencies, stimuli-responsive release, and stability against abiotic stressors. Plant assays confirmed that the encapsulated compounds exhibited enhanced bioavailability, prolonged activity, and improved performance compared to their free counterparts.