Abstract: This lecture follows the course of molecular recognition by synthetic receptors that completely surround their targets: encapsulation complexes. These operate through the proper filling of space and reveal new forms of stereochemistry, isomerism, asymmetry, contortions and reactivity of molecules held inside. Capsules with spacers offer a set of molecular devices that operate through compression and expansion of alkanes. An encapsulation complex of anandamide is shown below.
Biography: Julius Rebek, Jr. was born in Hungary in 1944 and lived in Austria from 1945-49. He and his family then settled in the U.S.A. in Kansas where they became naturalized U.S. citizens in 1954. He completed his undergraduate education at the University of Kansas in 1966, and received the Ph.D. degree from the Massachusetts Institute of Technology (1970) for studies in peptide chemistry. He has held positions at UCLA, U. Pittsburgh, and MIT. In 1996, he moved his research group to The Scripps Research Institute to become the Director of The Skaggs Institute for
Chemical Biology, where he continues to work in self-assembling systems and chemistry in small spaces. He was a Visiting Professor in the Chemistry Department of Fudan University, Shanghai, (2013-2016) under the Thousand Talents Program of China and is currently a Visiting Professor at Shanghai University.