ABSTRACT: The integration of a remotely controllable particles/cells manipulation in a lab on a chip system, including magnetoresistive sensors for molecular diagnosis, promises to play a key role towards the advancement in gene sequencing, single cell analysis and cell separation technology. Particularly, most existing single cell platforms are unable to achieve large scale operation with flexibility on cells and digital manipulation, and thus there is urgent need of innovative techniques to accomplish the automation of single cells. Recently, the flexibility of magnetic shuttling technology using nano/micro scale magnets for the manipulation of particles has gained significant advances and has been used for a wide variety of single cells manipulation tasks.
Here, we have developed a class of integrated micro-magnetophoresis platform for multiplex cells tweezers executing sequential and parallel, timed operations on an ensemble of single cells. When the magnetophoretic circuitry elements and logic gates are combined into arrays and driven by rotating magnetic field, the single cells/particles are precisely control for multiplexed analysis [1,2]. As for the rapid collection of specific cells, the concentric cells/particles transport to one point and then transported to apartments array were performed by the assembly of this magnetic track into a novel architecture, resembled with spider web network. Furthermore, a planar Hall resistance sensor was integrated at the center of the web networks, and the manipulation and monitoring are achieved via superparamagnetic bio-carriers .
This novel platform could possibly open a new biological assay system for both future diagnostic devices that overcomes diffusive bioanalytes transportation issues facing existing nano/micro-biosensors, and multiplexed magnetic tweezers which allows single cell heterogeneity and cellular interaction. Here, I will also review the application of spintronics devices for the physicomechanical monitoring of cardiovascular system .
 Byungwha Lim et al, Nature Communications, 5, 1(2014)
 Xinghao Hu et al, Small (2018) DOI: 10.1002/smll.201800504
 Byungwha Lim et al, NPG Asia Materials (2017) doi:10.1038/am.2017.37
 Sunjong Oh et al, Scientif Report (2017), DOI:10.1038/s41598-017-17277-2
BIOGRAPHY: CheolGi Kim received the B.S. degree from Seoul National University, Korea in 1983, and has completed his MS and Ph.D. from KAIST, Korea in 1986 and 1989. He was postdoctoral studies from NIST in USA. Prior to coming to DGIST in 2014, he has 24 years of research experience at KRISS and Chungnam National University in Korea, Tohoku (Japan), MaMaster (Canada) and Bielefeld (Germany) Universities. His research interests skate the intersection between nano-Spintronics and bio-medical sciences. During his Professional period, he published 260 reputed articles, and 25 patents. Especially, he is the Director of "Center for Bio-Convergence Spin System" and "Magnetics Initiative Life Care Center", directed to the novel bio-medical Spintronics device developments.
Professor Kim is currently a Professor and Dean of the Graduate School at DGIST, and co-director of VNU key laboratory, Vietnam. He has honored by 8 awards from domestic academic societies, and Distinction medal from Montpellier University in France. He has served as general Secretary of Asian Union of Magnetic societies during 2016-2017, and board member of Journal of Science: Advanced Materials and Devices.