14 OctChemical Science Student SeminarPoly(2-oxazolines): A new class of biomedical materials
Poly(2-oxazolines): A new class of biomedical materials
  • Nedah Al-Kattan, ChemS PhD Student, Supervised by Prof. Nikos Hadjichristidis
  • Sunday, October 14, 2018
  • 12:00 PM - 12:30 PM
  • Auditorium Between Buildings 4 & 5
2018-10-14T12:002018-10-14T12:30Asia/RiyadhPoly(2-oxazolines): A new class of biomedical materialsStudent Seminar Presentation Poly(2-oxazolines): A new class of biomedical materialsAuditorium Between Buildings 4 & 5Linda J. Sapolu

‚ÄčAbstract:  Poly (2-oxazolines) PAOx, known over 50 years, are mainly synthesized by using living cationic ring-opening polymerization (CROP) under microwave irradiation. Lately, the interest on PAOx has been increased, since thanks to their biocompatibility/biodegradability they found a wide range of applications mostly in the biomedical field, such as drug, protein, and gene delivery. In addition, PAOx are thermoresponsive materials and can be used to produce thermoresponsive self-assemblies. Two PAOx (2- methyl-2-oxazoline and 2- ethyl-2-oxazoline) have been synthesized in acetonitrile at 140 0C with methyl tosylate as initiator under microwave irradiation. The polymers have been characterized by Gel Permeation Chromatography (GPC), Nuclear Magnetic Resonance (1HNMR and 13CNMR), and Fourier Transform Infrared Spectroscopy (FTIR). In addition, their thermal properties were investigated by Differential Scanning Calorimetry (DSC). After these initial experiments, we are planning to synthesize PAOx-based block copolymers with different macromolecular architectures and evaluate them as potential candidates for drug delivery.

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  • Linda J. Sapolu

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